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音頻科普：幫助免疫系統(tǒng)對(duì)抗癌癥獲諾貝爾獎(jiǎng)
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音頻科普：幫助免疫系統(tǒng)對(duì)抗癌癥獲諾貝爾獎(jiǎng)
?James P. Allison and Tasuku Honjo share the Nobel Prize for their work on harnessing the cancer patient's own immune system to destroy tumors.James P. Allison和Tasuku Honjo因他們?cè)诶冒┌Y患者自身的免疫系統(tǒng)來(lái)摧毀腫瘤方面的工作分享了諾貝爾獎(jiǎng)。
撰文\播音：史蒂夫·米爾斯基（Steve?Mirsky）
翻譯：邱燕寧
審校：張清越
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“The Nobel Assembly at Karolinska Institute has today decided to award the 2018 Nobel Prize in Physiology or Medicine, jointly to?James P. Allison?and Tasuku Honjo for their discovery of?cancer therapy by inhibition of negative immune regulation.”
“今天，卡羅林斯卡學(xué)院的諾貝爾大會(huì)決定將2018年諾貝爾生理學(xué)或醫(yī)學(xué)獎(jiǎng)授予James P. Allison和Tasuku Honjo，以表彰他們發(fā)現(xiàn)了通過抑制負(fù)向免疫調(diào)節(jié)來(lái)治療癌癥的方法。”
Thomas Perlmann, secretary of the Nobel Assembly shortly after 5:30 this morning Eastern time.
美國(guó)東部時(shí)間今天上午5:30分后不久，諾貝爾大會(huì)秘書Thomas Perlmann如是說。
“James P. Allison was born in Alice, in Texas, in the United States. He performed his prize-winning studies at the University of California, Berkeley, and at Memorial Sloan Kettering Cancer Center in New York. He is now active at The University of Texas M. D. Anderson Cancer Center in Houston. Tasuku Honjo was born in Kyoto, in Japan. He performed his prize-winning studies at Kyoto University, where he is still active.”
James P. Allison在美國(guó)德克薩斯州的Alice出生。他在加州大學(xué)伯克利分校和紐約紀(jì)念斯隆凱特琳癌癥中心進(jìn)行了獲獎(jiǎng)研究。他現(xiàn)在就職于休斯頓的德克薩斯大學(xué)安德森癌癥中心。本卓生于日本京都。他在京都大學(xué)完成了他的獲獎(jiǎng)研究，現(xiàn)在仍在那里工作。
Karolinska Institute immunologist Klas K?rre, a member of the Nobel Committee, explained the significance of the work of the new Nobel laureates:
卡羅林斯卡研究所免疫學(xué)家Klas K?rre是諾貝爾委員會(huì)的成員，他解釋了新諾貝爾獎(jiǎng)獲得者的工作意義:
“Allison’s and Honjo’s discoveries have added a new pillar in cancer therapy. It represents a completely new principle, because unlike the previous strategies it is not based on targeting the cancer cells, but rather the brakes, the checkpoints, of the host immune system. The seminal discoveries by the two laureates constitute a paradigmatic shift and a landmark in the fight against cancer.”
Allison和Honjo的發(fā)現(xiàn)為癌癥治療增加了新的基石。它與之前的策略不同，代表了一個(gè)全新的理念，因?yàn)樗皇轻槍?duì)癌細(xì)胞，而是針對(duì)宿主免疫系統(tǒng)的檢查點(diǎn)。兩位獲獎(jiǎng)?wù)叩拈_創(chuàng)性發(fā)現(xiàn)構(gòu)成了一個(gè)范式轉(zhuǎn)變，也是抗擊癌癥的一個(gè)里程碑。
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?James P. Allison and Tasuku Honjo share the Nobel Prize for their work on harnessing the cancer patient's own immune system to destroy tumors.James P. Allison和Tasuku Honjo因他們?cè)诶冒┌Y患者自身的免疫系統(tǒng)來(lái)摧毀腫瘤方面的工作分享了諾貝爾獎(jiǎng)。
撰文\播音：史蒂夫·米爾斯基（Steve?Mirsky）
翻譯：邱燕寧
審校：張清越
?
“The Nobel Assembly at Karolinska Institute has today decided to award the 2018 Nobel Prize in Physiology or Medicine, jointly to?James P. Allison?and Tasuku Honjo for their discovery of?cancer therapy by inhibition of negative immune regulation.”
“今天，卡羅林斯卡學(xué)院的諾貝爾大會(huì)決定將2018年諾貝爾生理學(xué)或醫(yī)學(xué)獎(jiǎng)授予James P. Allison和Tasuku Honjo，以表彰他們發(fā)現(xiàn)了通過抑制負(fù)向免疫調(diào)節(jié)來(lái)治療癌癥的方法。”
Thomas Perlmann, secretary of the Nobel Assembly shortly after 5:30 this morning Eastern time.
美國(guó)東部時(shí)間今天上午5:30分后不久，諾貝爾大會(huì)秘書Thomas Perlmann如是說。
“James P. Allison was born in Alice, in Texas, in the United States. He performed his prize-winning studies at the University of California, Berkeley, and at Memorial Sloan Kettering Cancer Center in New York. He is now active at The University of Texas M. D. Anderson Cancer Center in Houston. Tasuku Honjo was born in Kyoto, in Japan. He performed his prize-winning studies at Kyoto University, where he is still active.”
James P. Allison在美國(guó)德克薩斯州的Alice出生。他在加州大學(xué)伯克利分校和紐約紀(jì)念斯隆凱特琳癌癥中心進(jìn)行了獲獎(jiǎng)研究。他現(xiàn)在就職于休斯頓的德克薩斯大學(xué)安德森癌癥中心。本卓生于日本京都。他在京都大學(xué)完成了他的獲獎(jiǎng)研究，現(xiàn)在仍在那里工作。
Karolinska Institute immunologist Klas K?rre, a member of the Nobel Committee, explained the significance of the work of the new Nobel laureates:
卡羅林斯卡研究所免疫學(xué)家Klas K?rre是諾貝爾委員會(huì)的成員，他解釋了新諾貝爾獎(jiǎng)獲得者的工作意義:
“Allison’s and Honjo’s discoveries have added a new pillar in cancer therapy. It represents a completely new principle, because unlike the previous strategies it is not based on targeting the cancer cells, but rather the brakes, the checkpoints, of the host immune system. The seminal discoveries by the two laureates constitute a paradigmatic shift and a landmark in the fight against cancer.”
Allison和Honjo的發(fā)現(xiàn)為癌癥治療增加了新的基石。它與之前的策略不同，代表了一個(gè)全新的理念，因?yàn)樗皇轻槍?duì)癌細(xì)胞，而是針對(duì)宿主免疫系統(tǒng)的檢查點(diǎn)。兩位獲獎(jiǎng)?wù)叩拈_創(chuàng)性發(fā)現(xiàn)構(gòu)成了一個(gè)范式轉(zhuǎn)變，也是抗擊癌癥的一個(gè)里程碑。
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